Helix-turn-helix motif
Web7 mrt. 2011 · The helix-turn-helix motif is another type of helical supersecondary structure that has been frequently found in DNA-binding proteins ( 19 ). The gp8.5 super helix coiled coil is a combination of the coiled coil and the helix-turn-helix supersecondary structures ( … WebThe motif interacts with DNA double helix and recognizes specific base sequences. It is assumed that the helix-turn-helix motif appears only once in seven prokaryotic …
Helix-turn-helix motif
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Web1 mrt. 2002 · Generally, transcriptional regulators contain one DNA-binding motif which consists of an α-helix-turn-α-helix motif. The second helix inserts into the major groove of target DNA and determine ... WebThe helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three super-kingdoms of life. At its core, the domain …
http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 Web13 okt. 2024 · 8ES1 Backbone modifications in the inter-helix loop of designed miniprotein oPPalpha: deltaOrn10-11 turn. PDB DOI: 10.2210/pdb8ES1/pdb BMRB: 31051 Classification: DE NOVO PROTEIN Organism(s): Streptococcus mutans Mutation(s): No Deposited: 2024-10-13 Released: 2024-04-05 Deposition Author(s): Harmon, T.W., …
WebThe helix-turn-helix DNA-binding motif is generally located in the N-terminal part of these transcriptional regulators. The C-terminal part may contain an oligomerization domain, … WebA basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.. bHLH transcription factors …
WebThe winged helix-turn-helix (wHTH) motif is formed by a 3-helical bundle and a 3- or 4-strand beta-sheet (wing). The topology of helices and strands in the wHTH motifs may vary. In the transcription factor ETS wHTH folds into a helix-turn-helix motif on a four-stranded anti-parallel beta-sheet scaffold arranged in the order α1-β1-β2-α2-α3 ...
WebInterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of … california sbe 911 registrationWeb4.2.2 The helix-turn-helix motif The simplest packing arrangement of a domain of two helices is for them to lie antiparallel, connected by a short loop. This constitutes the … california sb 996WebHELIX-TURN-HELIX MOTIF PREDICTION. [ Abstract ] [ NPS@ help ] [Original server] Sequence name (optional) : Paste a protein sequence below : help. california sbe certification applicationWebThe helix-turn-helix (HTH) domain is a common denominator in basal and specific transcription factors from the three super-kingdoms of life. At its core, the domain comprises of an open tri-helical bundle, which typically binds DNA with the 3rd helix. coastal storage concepts north myrtle beachHelix-turn-helix is a DNA-binding protein (DBP). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate … Meer weergeven The discovery of the helix-turn-helix motif was based on similarities between several genes encoding transcription regulatory proteins from bacteriophage lambda and Escherichia coli: Cro, CAP, and λ repressor, which were … Meer weergeven The helix-turn-helix motif is a DNA-binding motif. The recognition and binding to DNA by helix-turn-helix proteins is done by the two α helices, one occupying the N-terminal end of the motif, the other at the C-terminus. In most cases, such as in the Cro … Meer weergeven • Struhl K (April 1989). "Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins". Trends in Biochemical Sciences. 14 (4): 137–40. doi:10.1016/0968-0004(89)90145-X. PMID 2499084. • Gajiwala … Meer weergeven Several attempts have been made to classify the helix-turn-helix motifs based on their structure and the spatial arrangement of their helices. Some of the main types … Meer weergeven • DNA-binding domain • DNA-binding protein • Secondary structure Meer weergeven • Helix-turn-helix motif, lambda-like repressor, from EMBL • Full PDB entry for PDB ID 1LMB • Cro/C1-type HTH domain, more HTHs in PROSITE Meer weergeven coastal station reportsWeb15 sep. 1997 · The helical core domain is composed of a pair of entangled helix-turn-helix motifs; the fold of the core is similar to that of a DNA architectural factor. Highly … coastal stoneworksWebThe helix–turn–helix (HTH) structure was the first DNA-recognition motif identified in which an α -helical region is followed by a sharp β -turn and then another α -helical region. The … coastal storage heacham