Web20 mrt. 2015 · One especially important DNA repair pathway in this respect is homologous recombination (HR) repair. Defects in HR repair are observed in various cancers, including hereditary breast, and ovarian cancer. Intriguingly, tumor cells with defective HR repair show increased sensitivity to chemotherapeutic reagents, including platinum-containing … Web10 nov. 2016 · Conversely, unrestrained LTGC in BRCA mutant and other HR-defective cells might channel HR towards these deleterious outcomes as a mechanism of genomic instability in tumorigenesis [28–30]. In the cell lines studied here, non-canonical LTGC termination accounts for ~3% of all LTGCs in XRCC4 fl/fl cells, corresponding to ~0.1% …
Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient ...
WebChromosomal instability not only has a negative effect on survival in triple-negative breast cancer, but also on the well treatable subgroup of luminal A tumors. This suggests a general mechanism independent of subtypes. Increased chromosomal instability (CIN) in triple-negative breast cancer (TNBC) is attributed to a defect in the DNA repair pathway … WebThe HR repair system eliminates DNA double strand breaks (DSBs) that emerge during ICLs removal. The current study presents a novel cell line, CL‑V8B, representing a new … bobbi johnsoniss usa 196
Homologous recombination in cancer development, treatment a…
Web18 jul. 2016 · Unlike HR-defective cells, HR-proficient cells manifest very low cytotoxicity when exposed to PARPi, although they mount a DNA damage response. However, the genotoxic effects on normal human cells when agents including PARPi disturb proficient cellular repair processes have not been substantially investigated. WebThe data show that cells defective in HR (Xrcc2 and Brca2 mutants) are extremely sensitive to cell death by apoptosis and chromo- somal aberration formation and less … WebCells with defective HR are vulnerable to synthetic lethality if other DNA repair mechanisms in the HR- defective cells are inhibited. The DNA repair protein bobby joe sutton