WebJul 17, 2013 · Cerivastatin, the most lipophilic statin, was removed from the market owing to an unacceptably high rate of rhabdomyolysis. Details about the lipophilicity, potency, metabolism, and drug interactions of the various statins are provided in Table 1. Table 1 Selected properties of various statins View large WebBackground: To compare the risk of incident heart failure (HF) between initiators of hydrophilic and lipophilic statins. Methods: Using claims data for commercial health insurance program enrollees in the USA (2005-2014), we identified new initiators of hydrophilic or lipophilic statins. Follow-up for the primary outcome of incident HF began …
Lipophilicity - an overview ScienceDirect Topics
WebApr 23, 2013 · Within the statins, there are two distinct types identifiable by their lipophilicity. The type of statin used in CORONA and GISSI-HF is believed to have contributed to the unfavourable results in both trials and also may have skewed the outcomes of both meta-analyses towards the results of these two large trials. ... Table 1 … WebMay 28, 2015 · Most statin users were prescribed a lipophilic statin (93.4 %), with simvastatin being the most commonly prescribed type. Among current users, the percentages of participants using statins <2 years, 2–5 years, and >5 years were 15.1 %, 38.5 % and 46.4 % respectively. Table 2 Details of statin use in current users (N = 3,337) … download microsoft edge 2023
Effects of statin use on volumetric mammographic density: results from …
WebWe calculated the odds ratio for the association between intracranial hemorrhage and receipt of lipophilic statins, with hydrophilic statins as the reference group. Results: Conclusion: Among patients treated with a statin following ischemic stroke, the risk of intracranial hemorrhage is not influenced by statin lipophilicity. WebOct 26, 2024 · The incidence rates of MI, stroke, and fatal CVD events in each statin subgroup are shown in Table 3. There was no statistically significant difference in any of these outcomes between different statin uses according to type and lipophilicity. ... Yang YH, Hsu TW, Hsu CN (2024) Association of statin and its lipophilicity with cardiovascular ... WebMay 24, 2013 · Risk factors of statin-induced myotoxicity are patient pharmacogenetics [2, 65], statin lipophilicity and statin–drug interactions especially with CYP3A potent inhibitors such as azole antifungals or HIV/HCV PIs . Statin use has been associated with increases in hepatic transaminases. ... Table 4 indicates which statins are recommended with ... classical myth barry powell 9th edition ebook